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The Effects of Alcohol On Your Metabolism

Written by Schizoidman   
Monday, 19 May 2008


When alcoholic drinks are consumed they pass through the stomach into the small intestine where the ethanol (the key ingredient of alcohol) is rapidly absorbed and distributed throughout the body. The ethanol enters body tissues in proportion to their water content. Therefore, more ethanol is found in the blood and the brain than in muscle or fat tissue. Ethanol is greatly diluted by body fluids. A 1-ounce shot of 100-proof whiskey, which contains 0.5 fluid ounces of ethanol (or 15 mL), is diluted 5000-fold and in a 150-pound human, producing a 0.02% blood alcohol concentration.

Ethanol is toxic, and the body begins to dispose of it immediately upon its consumption. The liver processes over 90% of it. In the liver, the alcohol dehydrogenase enzyme converts ethanol into acetaldehyde, which is, toxic.

Studies have shown that in the short term, alcohol stimulates food intake and can also accentuate subjective feelings of hunger. Other studies have shown that the stimulatory effects of alcohol on food intake are controlled by hormonal regulation of satiety and satiation, such as the hormone leptin. Regardless of the cause, the outcome is the same; people consume more food when they have consumed alcohol.

Your body considers alcohol a poison, and all efforts are made to excrete it, including the cessation of maintaining healthy blood glucose levels. Studies have shown that alcohol interferes with all three sources of glucose and the hormones needed to maintain healthy blood glucose levels. The greatest impact is seen in those who drink heavily on a frequent basis. Heavy drinkers deplete their glycogen stores within a few hours when their diet does not provide a sufficient amount of carbohydrates. Over time, excessive alcohol consumption can decrease insulin's effectiveness, resulting in high blood sugar levels. One study showed that 45% to 70% of people with alcoholic liver disease had either glucose intolerance or diabetes.

There is also an increased risk of problems when combining exercise and alcohol. It is not uncommon for people to go out for a drink after playing sports (for example, hockey, soccer, tennis) or to consume some alcoholic beverages while playing. Your blood sugars naturally drop during exercise, and your body is working on replacing your glycogen stores once you are finished. Consuming alcohol during this time will halt this process and can cause blood sugar levels to stay at an unhealthy level.

Regulating your calorie consumption is the key to successful weight loss and maintenance. A balanced diet will assist with curbing your hunger and providing the necessary nutrients for health and wellness. Alcohol is not considered a necessary component in a healthy diet. Instead, it provides a lot of calories and negatively impacts many aspects of your health.

Does Alcohol have any health benefits?

Despite what the popular media tells you, consumption of high amounts of alcohol is not healthy for you. When alcohol is metabolized there are potentially toxic products resulting from the breakdown of alcohol. The major alcohol-metabolizing enzymes are alcohol dehydrogenase and cytochrome P450 2E1 (CYP2E1). The enzyme, alcohol dehydrogenase converts alcohol to acetaldehyde, which can react with other proteins in the cell to generate hybrid molecules known as adducts. These hybrid protein molecules can cause cell degeneration or damage. CYP2E1 also generates acetaldehyde, as well as highly reactive oxygen-containing molecules called oxygen radicals, including the hydroxyethyl radical (HER) molecule. Elevated levels of oxygen radicals can generate a state of oxidative stress, which through various mechanisms leads to cell damage.  It depresses the central nervous system and can also precipitate cardiac arrhythmia. Modest concentrations depress inhibitory neurons, thereby turning the introvert into a talkative exhibitionist. With higher concentrations there is an impairment of cerebella function, causing slurred speech, poor hand-eye coordination and unsteadiness. Subsequently, sensation, consciousness, and then brainstem functions are depressed. Alcohol also has a heightened affect on the Hypothalamus. This is the inhibitory region of the brain. One of the principle things that the hypothalamus is responsible for is inhibiting sexual and anger impulses.

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